Dr Gary Fettke - Nutrition and cancer – Time to rethink

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Nutrition and cancer – Time to rethink Dr Gary Fettke In 1931 Otto Warburg received the Nobel Prize for showing that cancer cells have an absolute requirement to use glucose for their energy requirements since they lack proper mitochondrial function for oxidizing fats. This suggests that nutritional factors in particular low or high carbohydrate diets might influence cancer outcomes differently. In my presentation I will present the evidence showing that certain cancers may be carbohydrate-dependant and may be positively influenced by the ingestion of low carbohydrate ketogenic diets which reduce the provision of glucose to the tumour cells. Cancer as a metabolic disease Seyfried T N et al. Carcinogenesis 2013;carcin.bgt480 http://carcin.oxfordjournals.org/content/early/2014/01/18/carcin.bgt480.long Cancer Statistics, Trends, and Multiple Primary Cancer Analyses from the Surveillance, Epidemiology, and End Results (SEER) Program http://theoncologist.alphamedpress.org/content/12/1/20.long Fouche FP: Freedom of Negro Races from Cancer, Br Med J. 1923 Jun http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2316860/ Renehan G et al. Obesity and Cancer: Physiological and biological mechanisms. Archives of Physiology and Biochemistry, 2 2008; 114(1): 71-83 http://informahealthcare.com/doi/abs/10.1080/13813450801954303 Giovannucci et al. Diabetes and cancer: a consensus report. CA Cancer J Clin 2010;60:207-221 http://onlinelibrary.wiley.com/doi/10.3322/caac.20078/full Understanding the Warburg effect: the metabolic requirements of cell proliferation. Vander Heiden et al. Science 2009; science. 1160809 http://www.ncbi.nlm.nih.gov/pubmed/19460998 Cancer cells metabolically “fertilize” the tumor microenvironment with hydrogen peroxide, driving the Warburg effect Lisanti et al. Cell Cycle, 2011; 10(15) 2504-2520 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180189/ Chan et al, Are we ready to recommend aspirin for the prevention of cancer? Lancet. Apr 28,2012; 379(9826): 1569-1571 http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)61654-1/abstract Decensi et al, Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res, 2010 Nov;3(11):1451-61 http://cancerpreventionresearch.aacrjournals.org/content/3/11/1451.short Lee et al, Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese. BMC Cancer. 2011;11:20 http://www.biomedcentral.com/1471-2407/11/20/ Lv M, Zhu X, Wang H, Wang F, Guan W (2014) Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting during Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis. PLoS ONE 9(12): e115147. doi:10.1371/journal.pone.0115147 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115147 Schmidt et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: a pilot trial. Nutrition & Metabolism 2011, 8:54 http://www.nutritionandmetabolism.com/content/8/1/54 Fine et al. Nutrition, Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. 28 (2012) 1028-1035 http://www.ncbi.nlm.nih.gov/pubmed/22840388 Rieger et al. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int Journ Oncology 44: 1843-1852, 2014 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063533/ Champ, Volek et al. 2014. Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. Jour Neurooncology DOI 10.1007/s11060-014-1362-0 http://www.ncbi.nlm.nih.gov/pubmed/24442482 Human Clinical Trials https://clinicaltrials.gov/ct2/results?term=ketogenic+diets+and+cancer&Search=Search Raffaghello et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high dose chemotherapy. PNAS. 2008 http://www.pnas.org/content/105/24/8215.short Klement and Champ. 2014 Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation. Cancer Metastasis Rev. 2014; 33(1): 217–229 http://www.ncbi.nlm.nih.gov/pubmed/24436017 Novotny et al. A pessimistic explanatory style is prognostic for poor lung cancer survival. Jour Thoracic Oncology 2010 5(3):326-32 http://www.ncbi.nlm.nih.gov/pubmed/20139778 Popkin et al. 2010,. Does hunger and satiety drive eating anymore? Increasing eating occasions and decreasing time between eating occasions in the United States Am J Clin Nutrition, 91: 1342-1347 http://www.ncbi.nlm.nih.gov/pubmed/20237134 No Fructose http://www.nofructose.com/
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